Obviously it is possible! Both multi-symbol and multi-timeframe indicators have existed even on MT4.
But, since you are asking about MT5, here are some examples of multi-symbol indicators coded in MQL5 ...
In MT4 - MTF indicators can be use for regular charts timeframe (M1,M5,M15, H1, H4, etc) and offline charts custom timeframe (M7,M23,M37,M52, etc)
Also in MT4 - Multi Symbols indicators purely for displaying different symbols - not for custom timeframe
But in MT5 - offline charts is not available - the work around MT5 limitation have to use custom symbols
MTF indicators cannot be use for offline charts in MT5 because custom timeframe not available
Must use Multi Symbols indicators because offline charts created in different symbols charts (not in custom timeframe charts as in MT4)
It is not a "limitation". Custom Symbols on MT5 is superior in functionality to that of Offline Charts on MT4.
That is an inaccurate statement due to your lack of understanding of how Custom Symbols work on MT5.
Again, it is a lack of understanding. Even on MT4 Offline Charts could be generated with a different symbol name, not just a different faux time-frame.
Custom Symbols on MT5 is an evolution of the Offline Charts with much more functionality and flexibility.
Be it multi-symbol or multi-timeframe, the concept is exactly the same. Calling custom indicators always require both parameters (i.e. Symbol and Time-frame). So, implementing one or the other is exactly the same.

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MTF MA indicator in M21 timeframe perfectly displaying Moving Average condition from bigger timeframe (M31)