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Dimitri Nepomniachtchi  
If you have an EA that showed a big loss when tested on a fixed lot. Then you can run it in the opposite direction.
But don't rush, the formula is simple.
The number of closed orders x(spread x2).
Closed profit, subtract the result from it.
This result could have been if you had traded during the test period in the strategy tester
and if the result is decent, then you can run the risk lot from the dedicated balance for the EA.
Best regards :) 
I will be glad to answer your questions.