451 Update Problems with Alerts

 
System updated on Sunday with Build 451.   Mail service no longer works.   I have reset smtp on router,  25 and 587.   I deleted email.ini.   I have even set to different smtp servers.   Same error message.   Mail: Error connecting to smtp.XXXX.com.     No matter where I put it.    Any suggestions.
 
Did you install in \program files* on Vista/win7?
Reason: